Gel-Based Human Topoisomerase I DNA relaxation Assay

Drug Discovery, Drug Delivery, and Biochemical Assays

ProFoldin’s products and services are employed by universities, research institutes, biotech

companies, pharmaceutical R&D and research hospitals worldwide in life sciences and drug discovery.

Gel-Based Human Topoisomerase I DNA relaxation Assay

Human DNA topoisomerase I (topo I) converts supercoiled circular DNA into relaxed DNA (DNA relaxation reaction). The Gel-Based Human Topoisomerase I DNA relaxation Assay Kit is based on the principle that the supercoiled DNA and relaxed DNA are separated by agarose gel electrophoresis. Fluorescence-based DNA relaxation assays in a 96-well pate format are also available for high throughput screening of human topo I inhibitors.